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| 艾普拉唑与雷贝拉唑治疗十二指肠溃疡的药物经济学评价 |
| Pharmacoeconomic Evaluation of Ilaprazole and Rabeprazole for Duodenal Ulcer |
| 投稿时间：2012-06-18 修订日期：2012-08-20 |
| DOI： |
| 中文关键词: 艾普拉唑 雷贝拉唑 十二指肠溃疡 药物经济学 |
| 英文关键词:Ilaprazole Rabeprazole Duodenal ulcer Drug economics |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：评价艾普拉唑和雷贝拉唑治疗十二指肠溃疡的有效性、安全性和经济性。方法：259例十二指肠溃疡患者随机分为试验组129例和对照组130例， 试验组予艾普拉唑肠溶片5 mg，po qd；对照组予雷贝拉唑肠溶片10 mg，po qd，疗程均为28 d；两组均采用克拉霉素片500 mg+甲硝唑片400 mg治疗，po bid，疗程7 d。结果：4周胃镜下溃疡显效率试验组92.25%，对照组为90.00%（P >0.05），不良反应发生率分别为10.08%和10.77%(P >0.05)。试验组和对照组成本分别为1 739.26元和1 814.79元。结论：艾普拉唑和雷贝拉唑均为治疗十二指肠溃疡的有效药物，但艾普拉唑略为经济。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the effectiveness, safety and economy of ilaprazole and rabeprazole in the treatment of duodenal ulcer.Methods:259 cases of patients with duodenal ulcer were randomly divided into the treatment group(130) and controlled group(129). The treatment group took ilaprazole 5 mg, po qd for 28d and the controlled group, rabeprazole 10 mg, po qd. The two groups used clarithromycin tablets 500mg + metronidazole 400mg, po bid for 7 d.Results:The ulcer healing rate was 92.25% under the gastroscope examination for the treatment group 4 weeks later and 90.00% for the controlled group (P >0.05). The incidence of adverse reactions was 10.08% and 10.77%, respectively (P >0.05). The costs of the treatment group and the controlled group were 1739.26 yuan and 1 814.79 yuan. Conclusion:Ilaprazole and rabeprazole were the effective drugs in the treatment of duodenal ulcer, but ilaprazole was slightly more economical. |
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