| ABSTRACT Objective:To analyze major varieties of drugs with adverse drug reactions(ADRs) in our hospital to provide reference for clinical rational drug use. Methods:136 ADR cases collected in hospital from 2008 to 2011 were statistically analyzed in respect of number of case，drugs with frequent ADR and clinical manifestation. etc.Results:In the 136 ADR events, the female showed higher proportion than the males, and the senile patients aged ≥60 accounted for about 41.18%, and the patients aged ≤10, for about 39.71%; anti infective drugs and traditional Chinese medicines dominated the first two places stably in terms of number of varieties. The ADRs were more frequently induced by antibiotics(48.53%),followed by traditional Chinese medicine(40.44%); The ADRS were mostly induced by intravenous administration, and lesions of skin and its appendages were the most frequent, accounting for 53.68%. Conclusion:Antibiotics should be rationally used in accordance with the “Guiding Principles of Clinical Use of Antibiotics”; meanwhile, the clinical use of Chinese medicine preparations should be standardized, and popularization of the knowledge of safe use of Chinese medicines should be strengthened in order to ensure safe and effective drug use for patients. |
