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| 阿托伐他汀对慢阻肺患者血浆炎症细胞因子的影响及疗效观察 |
| The Influence and Curative Effect of Atorvastatin on Plasma Level of Inflammatory Cytokines of Patients with Chronic Obstructive Pulmonary Disease |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 阿托伐他汀 炎症细胞因子 疗效 |
| 英文关键词:COPD Atorvastatin Inflammatory cytokines Efficacy |
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| 中文摘要: |
| 摘 要 目的：探讨阿托伐他汀对慢性阻塞性肺病(COPD)患者血浆炎症细胞因子的影响及疗效。方法：80例COPD住院患者分为观察组和对照组各40例,对照组予吸氧、抗感染、止咳化痰及平喘等常规对症治疗;观察组在此基础上口服阿托伐他汀片20 mg，qd ，连用4周。观察两组治疗前后血浆IL-6、IL-8和IL-10水平的变化，并比较两组疗效及不良反应。结果：治疗4周后，两组患者血浆IL-6和IL-8水平均较治疗前明显下降，血浆IL-10水平较治疗前明显上升(P<0.05或0.01)，且观察组下降或上升的幅度明显优于对照组(P<0.05)。观察组总有效率明显高于对照组(P<0.05)。两组不良反应症状均较轻，不良反应发生率比较，差异无统计学意义(P>0.05)。结论：阿托伐他汀治疗COPD的疗效确切，安全性较好，作用机制与其能调节血浆炎症细胞因子的水平密切相关。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the influence and curative effect of atorvastatin on plasma level of inflammatory cytokines of patients with chronic obstructive pulmonary disease(COPD). Methods:80 COPD inpatients were divided into observation group(40 cases) and control group(40 cases). All the patients got fundamental treatment as oxygen uptaking, anti infection, cough relieving, sputum reducing, asthma relieving, and patients of observation group got extra treatment as taking atorvastatin tables orally 20mg once a day, for 4 weeks. Results:The plasma levels of IL-6 and IL-8 descended significantly comparing with 4 weeks before treatment, but the level of IL 10 ascended(P<0.05 or P<0.01), and the rangeability of observation group was more significantly obviously than that of control group(P<0.05). The total clinic effective rate of observation group was significantly higher than that of control group(P<0.05). Adverse drug reaction were slight both of the two groups.There was no significant difference of adverse reaction rate between the two groups(P>0.05).Conclusion:Treating COPD patients with atorvastatin shows safe and effective, it may works through regulating the plasma level of inflammatory cytokines. |
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