| ABSTRACT Objective:To probe into the characteristics of adverse drug reactions(ADR) caused by PEG-interferon alfa-2a injection to provide some rational clinical guidance. Methods:1606 reports of adverse reactions caused by PEG-interferon alfa-2a injection were collected from January 2004 to December 2011 and statistically analyzed in respect of patients' sex and age, involved type, years, result, clinical manifestations, etc.Results:883 of the 1606 cases were male cases,723 were female cases, and 72.6%were the adults at the age of 30 to 60. The incidence rate of severe ADR were 243 cases, and new and severe ADR were 86 cases. The blood system was the main lesion in ADR cases (59.95%), and the second was liver and gall system(10.76%).Conclusion:The corresponding adverse reactions should be closely observed during the clinical use of PEG interferon alfa 2a in the treatment of hepatitis C. The occurrence of adverse reactions could be effectively reduced and prevented by making a careful nursing plan and conducting an active intervention and control. |
