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| 还原型谷胱甘肽治疗药物性肝炎疗效观察 |
| The Therapeutic Effects and Safety of Reductive Glutathione in Patients with Drug Induced Hepatitis |
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| DOI： |
| 中文关键词: 药物性肝炎 还原型谷胱甘肽 硫普罗宁 |
| 英文关键词:Drug induced hepatitis Reductive Glutathione Tiopronin |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：观察还原型谷胱甘肽治疗药物性肝炎的临床疗效及安全性。方法：68例药物性肝炎患者随机分为治疗组与对照组各34例。治疗组采用还原型谷胱甘肽注射液治疗，对照组采用硫普罗宁注射液治疗， 20天为1疗程，比较两组疗效及安全性。结果：治疗组总有效率为94.1％（32/34），对照组总有效率为78.8％（26/33），两组比较，差异有统计学意义(P<0.05)。两组患者治疗后血清ALT、AST 、TBIL比较，差异有统计学意义（P<0.05)。治疗组未发生药品不良反应，对照组发生5例药品不良反应（15.2%），2组比较，差异有统计学意义(P<0.05)。结论：还原型谷胱甘肽治疗药物性肝炎的临床疗效及安全性优于硫普罗宁。 |
| 英文摘要: |
| ABSTRACT Objective:To observe the therapeutic effects and safety of reductive glutathione in patients with drug induced hepatitis. Methods:68 patients with drug induced hepatitis were randomly divided into the observation group (34 cases) and the controlled group (34 cases) . The observation group was given reductive glutathione injection, and the controlled group were given tiopronin injection. The therapeutic effects and safety of the two groups were contrasted after 20 days course of the treatments.Results:The total effective rate of the observation group was 94.1%(32/34). That of the controlled group was 78.8%(26/33). There was only 33 cases with one case quit in the controlled group because of his allergic shock on the first therapy day.There was statistical significance between the two groups (P<0.05). There was also statistical significance about ALT, AST and TBIL in the two groups after therapy. The therapeutic group had no ADR(0%), while the controlled group had 5 cases of ADR(15.2%). There was statistical significance between the two groups(P<0.05). Conclusion: The application of reductive glutathione in the treatment of patients with drug induced hepatitis had a better effect than that of tiopronin. |
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