| ABSTRACT Objective:To investigate the types of causative agents, clinical pathological features, and related prognosis factors of elderly patient with drug induced liver disease（DILI）in order to improve the diagnosis and treatment of DILI. Methods:72 elderly patients with DILI admitted to our hospital from February 2009 to February 2012 were retrospectively reviewed according to their drug history, clinical features, lab tests, pathological characteristics, and related prognosis factors. Results:The primary etiological drugs of elderly patient with DILI were herbal medicine（59.8%），hypoglycemic agents（11.1%），cardiovascular drugs（9.7%），antibiotics （8.3%）and anti tuberculosis drugs（6.9%）. Their DILIs were 15 cases of drug induced liver failure （20.8%％）,36 cases of acute DILI （50％）and 17 cases of chronic DILI （23.6％）, 4 cases of drug induced live cirrhosis （5.6％）, respectively. The predominant pathology of DILI was hepatocyte necrosis，hepatocyte hydropic degeneration，hepatocyte fatty degeneration，hepatic portal area enlargement，fibroplasia，eosinophils infiltration，mixed inflammatory cell infiltration in hepatic portal area or hepatic sinusoid, cholestasis，hepatocyte apoptosis and Kupffer cell proliferation. Conclusion:The DILI in elderly patients had the different types of causative agents but no specific clinical manifestation. Elderly patients with DILI had the higher mortality（5.6%vs2.6%）. Therefore, their hepatic function should be dynamically monitored in the application of related drugs to diagnose and treat them early. |
