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| 奥曲肽治疗肢端肥大症疗效及安全性的Meta分析 |
| Meta analysis of the Effect of Octreotide in the Treatment of Acromegaly |
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| DOI： |
| 中文关键词: 奥曲肽 肢端肥大症 Meta分析 |
| 英文关键词:Octreotide Acromegaly Meta analysis |
| 基金项目:国家自然科学基金资助项目（编号：81171119） |
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| 中文摘要: |
| 摘 要 目的：系统评价奥曲肽治疗肢端肥大症的疗效。方法：计算机检索Cochrane图书馆、Medline、Embase、中国生物医学文献数据库（CBM）、中国学术期刊全文数据库（CNKI）、万方数据库，根据Cochrane系统评价方法对纳入的随机对照实验（RCT）进行方法学评价，并应用Revman5.0软件进行Meta分析。结果：共纳入5个RCT，共计218例患者。Jadad评分均>3分。Meta分析结果显示：实验组干预后的血清GH及IGF 1的浓度低于对照组［MD=-19.15，95%CI(-24.32，-13.98)］及［MD=-21.37，95%CI(-26.15，-16.58)］，实验组肿瘤体积缩小率大于对照组［RR=24.25，95%CI(4.87，120.79)］，实验组腹泻的发生率与对照组的差异无统计意义［RR=1.69，95%CI(0.78，3.64)］。结论：奥曲肽能安全有效的降低肢端肥大症患者血清GH和IGF 1的浓度，并有利于缩小肿瘤体积。由于纳入试验质量和病例数的限制，该结论需进一步的研究证实。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the effects of octreotide in the treatment of acromegaly．Methods:The Cochrane Library，Mediline，Embase，CBM，Wanfang and CNKI databases were searched．The method and Revman 5.0 by the Cochrane Collaboration were used to perform a meta analysis of randomized controlled trails (RCTs)．Results:5 RCTs were included and 218 patients were involved in the study． Jadad scores were more than 3 points． The results of the meta analysis demonstrated that octreotide was superior to placebo in decreasing the concentration of GH and IGF 1(［MD=-19.15，95%CI(-24.32，-13.98)］，［MD=-21.37，95%CI(-26.15，-16.58)］)，and octreotide was more effective to reduce the tumor volume［RR=24.25，95%CI(4.84，120.79)］，but there was no statistically significant difference in the incidence of diarrhea in the experimental group and the placebo group ［RR=1.69，95%CI(0.78，3.64)］. Conclusion:Octreotide could safely and effectively lower serum GH and IGF-1 concentration in patients with acromegaly and shrink the tumor volume．Due to limitation of the induded trials, this conclusion needs to be validated by further studies. |
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