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| Bootstrap法对顺铂为基础晚期食管癌化疗短期疗效的经济学分析 |
| Qingdao Municipal Hospital Affiliated to Medical College of Qingdao University，Qingdao 266071，Shandong, China |
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| DOI： |
| 中文关键词: 顺铂 食管癌 化疗 Bootstrap法 药物经济学 |
| 英文关键词:Cisplatin Esophageal cancer Chemotherapy Bootstrap Method Pharmacoeconomics |
| 基金项目:2011年青岛市科技局立项课题（编号11-2-3-2-(6)-nsh） |
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| 中文摘要: |
| 摘 要 目的：：用Bootstrap法对3种顺铂为基础的联合化疗方案在晚期食管癌化疗短期疗效进行药物经济学分析。方法：采用回溯法筛选114例食管癌病例，分成3组，分别为Ⅰ组丝裂霉素、氟尿嘧啶联合顺铂（PMF）方案，Ⅱ组紫杉醇联合顺铂（TD）方案，Ⅲ组依托泊苷、氟尿嘧啶联合顺铂（PEF）方案。比较3组疗效及成本 效果比，用Bootstrap方法分析结果。结果：3组疗效分别为46.15%，47.36%，43.24%。成本-效果比(元/例)分别为36 677，42 345，37 946。以成本最低的Ⅲ组为对照，I组和II组的增量费用效果比(ICER)分别为17 828，85 512。同样以PEF方案为对照进行Bootstrap分析，两组的ICER的平均值分别为17 355，88 118，表明敏感性分析结果稳定性好，可信性高。结论：PMF方案积具有较好的药物经济学意义。 |
| 英文摘要: |
| ABSTRACT Objective:To analyze the cost effectiveness of combined chemotherapy containing short term cisplatin treatment of advanced esophageal cancer with bootstrap. Methods: 114 patients diagnosed as carcinoma of the esophagus were randomly divided into 3 treatment groups. Group Ⅰ was PMF which was given mitomycin and 5-FU and cisplatin .Group Ⅱ was TD which was given taxol and cisplatin. Group Ⅲ was PEF which was given VP 16 and 5-FU and cisplatin. The three groups were assessed by clinical evaluation of pharmacoepidemiology and cost effectiveness analysis of pharmacoeconomics. Results: The clinical effectiveness of Group Ⅰ, Ⅱ and Ⅲ was 46.15%，47.36%，43.24%, respectively. The ratio of cost effectiveness of Group Ⅰ, Ⅱ and Ⅲ was 36 677,42 345,37 946. With the lowest cost group (PEF) as the cross reference, the ICERs of Group Ⅰ and Ⅱ were 17 828 and 85 512. Similarly with the PEF as the cross reference to make Bootstrap analysis, the ICER averages of Group Ⅰ and Ⅱ were 17 355 and 88 118, which indicated the good stability and high credibility of the results of the sensitivity analysis. Conclusion:The PMF group was the best one in the cost effectiveness. |
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