| ABSTRACT Objective:Discussion of monitoring in patients with malignant tumor chemotherapy before concurrent bacterial infection of serum procalcitonin ( PCT ) levels on clinical optimization of antimicrobial drug use value. Methods:114 cases were divided into observation group and control group. The control group (45 cases) was treated with conventional therapy, according to the clinical symptoms of patients with selection of antibacterial drugs; The observation group (69 cases) monitoring serum PCT level, super sensitive c reactive protein (hsCRP), blood routine and the change of blood culture ,pursuant to which the formulation of to optimize antibacterial drug scheme. Observation two groups antibacterial treatment, hospitalization days, antibacterial drug costs, antibacterial use density (AUD),as well as the incidence of superinfection and adverse drug reactions (ADR). Results:The observation group patients serum PCT levels with bacterial infection in patients with severe degree. The Observer Group antibacterial drug treatment, the number of days of hospitalization, antimicrobial drugs costs, AUD, as well as the superinfection and ADR etc indicators are better than the control group, the difference was statistically significant (P<0.05 or 0.01). Conclusion: Monitoring of PCT dynamic value on malignant tumor before chemotherapy patients with bacterial infection before the diagnosis and clinical antibacterial short term optimal treatment has the practical value. |
