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| 64例别嘌醇引起皮肤系统损害分析 |
| Analysis of 64 Cases Adverse Skin Reactions Caused by Allopurinol |
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| DOI： |
| 中文关键词: 别嘌醇 药品不良反应 皮肤系统 皮疹 痛风 |
| 英文关键词:Allopurinol Adverse drug reaction Skin system Rash Gout |
| 基金项目:浙江省康恩贝医院管理软件项目(编号：2009AZHA-211) |
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| 中文摘要: |
| 摘 要 目的：探讨别嘌醇引起皮肤系统不良反应的表现及发生规律，为临床安全用药提供参考。方法：我院不良反应监测系统2005年1月～2012年3月使用别嘌醇引起的皮肤系统不良反应病例进行统计分析。结果：共检索到ADR 64例，以中老年居多（51例，79.7%），其常用日剂量为50～100 mg（51例，79.7%），潜伏期2 d～4个月不等；皮肤系统ADR的临床表现以一般型、剥脱性皮炎型及多形红斑型的药疹为主，占73.4%，60%患者有伴随症状。结论：临床应重视别嘌醇皮肤系统不良反应的危害性。对老年患者更应注意密切观察用药后反应,确保用药安全。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expressions and rules of adverse drug reactions induced by allopurinol and provide references for rational clinical drug use. Methods:Adverse reaction cases of allopurinol were collected from the Adverse Reaction Monitoring Center of Wenzhou Medical College from January 2005 to March 2012, and the manifestation in skin damage, analyzed. Results:The adverse reactions occurred more easily to the middle aged and old men（51 cases,79.7%） in the 64 cases, and the latent period was 2-95d. The skin damages were mainly presented as common types, drug induced epidermolysis, drug induced exfolialive dermatitise which took up a total of 73.4%, and 60%. The patients had some accompanying symptoms. Conclusion:Importance should be attached to the skin damage induced by allopurinol. Reactions should be closely observed to ensure the safety of drug use, especially for elderly patients after treatment. |
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