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| 207例次万古霉素与去甲万古霉素血药浓度监测及个体化给药 |
| Monitoring of Blood Concentration and Individualized Administration of Vancomycin and Norvancomycin in 207 Cases |
| 投稿时间：2012-01-04 修订日期：2012-02-20 |
| DOI： |
| 中文关键词: 万古霉素 去甲万古霉素 血药浓度监测 个体化给药 |
| 英文关键词:Vancomycin Norvancomycin Therapeutic drug monitoring Individualized administration |
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| 中文摘要: |
| 摘 要 目的：分析207例次万古霉素和去甲万古霉素血药浓度监测情况，为临床合理用药提供依据。方法：采用高效液相色谱法测定万古霉素和去甲万古霉素血药浓度，对本院2005～2011年207例次万古霉素和去甲万古霉素血药浓度监测结果进行回顾性分析。结果：35例使用万古霉素的患者中监测血峰、谷浓度103例次，峰浓度和谷浓度在治疗窗范围内的各占65.31%和42.60%。35例使用去甲万古霉素的患者中监测血峰、谷浓度104例次，峰浓度和谷浓度在治疗窗范围内的各占32.65%和16.36%。>60岁组的万古霉素和去甲万古霉素谷浓度均显著高于<18岁组（P<0.05）。应用万古霉素或去甲万古霉素前后，肾功能无明显差异（P>0.05）。不良反应发生率为21.42%。结论：万古霉素和去甲万古霉素血药浓度监测有利于实现个体化给药，从而保证临床用药的安全有效。 |
| 英文摘要: |
| ABSTRACT Objective: To analyse the monitoring result of blood concentration of vancomycin and norvancomycin in 207 cases and provide evidence for rational use of these drugs.Methods:High performance liquid chromatography was used to determine the blood concentration of vancomycin and norvancomycin.The monitoring results of blood concentration of vancomycin and norvancomycin in 207 cases in a hospital from 2005 to 2011 were analyzed retrospectively. Results:Among 35 patients treated with vancomycin, peak and trough concentrations in 103 cases were determined. Peak and trough concentrations within the normal range were 65.31% and42.60%. Among 35 patients treated with norvancomycin, peak and trough concentrations in 104 cases were determined. Peak and trough concentrations within the normal range were 32.65% and 16.36%. Trough concentrations of vancomycin and norvancomycin in the group older than 60 years were significantly higher than those in the group younger than 18 years（P<0.05）. There were no statistically significant differences between renal function before and after treatment with vancomycin or norvancomycin（P>0.05）.The rate of adverse reactions induced by vancomycin and norvancomycin was 21.42%. Conclusion:The monitoring of blood concentration of vancomycin and norvancomycin will benefit individualized administration so as to guarantee the safety and efficacy of these two drugs. |
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