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| 根除幽门螺杆菌对胰岛素抵抗、血脂及C反应蛋白的影响 |
| Effect of Helicobacter Pylori Eradication on Insulin Resistance,Serum Lipids and C Reactive Protein |
| 投稿时间：2012-05-29 修订日期：2012-07-06 |
| DOI： |
| 中文关键词: 幽门螺杆菌 胰岛素抵抗 血脂 C反应蛋白 |
| 英文关键词:Helicobacter pylori Eradication Insulin resistance Serum lipids C reactive protein |
| 基金项目:佛山市卫生局基金资助项目（编号：2011366） |
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| 中文摘要: |
| 摘 要 目的：观察根除幽门螺杆菌(Hp)对胰岛素抵抗(IR)、血脂及C反应蛋白(CRP)的影响。方法：92例确诊为Hp现症感染的患者随机分成治疗组和对照组，分别接受雷贝拉唑10 mg+克拉霉素500 mg+甲硝唑400 mg，bid的根除Hp治疗和安慰剂。治疗前和8周后分别测定空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及C反应蛋白（CRP）水平，计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果：治疗组Hp根除率为78.2%(36/46)。治疗后治疗组Hp根除者TC、TG、LDL-C、CRP、HOMA-IR均显著下降，HDL-C显著上升（P＜0.05）。对照组上述指标治疗前后无明显改变（P＞0.05）。结论：Hp根除治疗能改善IR、血脂及CRP水平。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the effects of Hp eradication on insulin resistance（IR）, serum lipids and C reactive protein（CRP）. Methods:92 patients with Hp infection were randomly allocated to two groups of 46 patients each and treated with rabeprazole 10 mg+clarithromycin 500 mg+metronidazole 400 mg twice daily and placebo respectively for 7 days. HOMA-IR, TC, TG, LDL-C，HDL-C and CRP were measured before the eradication therapy and 8 weeks after its end in each group. Results:The eradication rate was 78.2% (36/46) in the treatment group. TC，TG，LDL-C，CRP，HOMA-IR in patients with successful eradication were significantly decreased and HDL-C was significantly increased from the pretreatment levels(P<0.05). Conclusion:Hp eradication can significantly improve their insulin resistance, serum lipids and C reactive protein. |
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