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| 多奈哌齐干预老年轻度认知功能障碍的临床研究 |
| Clinical Study of Intervention in Mild Cognitive Impairment by Donepezil in Elderly Patients |
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| DOI： |
| 中文关键词: 轻度认知功能障碍 多奈哌齐 蒙特利尔认知评估量表 认知电位P300 |
| 英文关键词:Mild cognitive impairment Donepezi Montreal Cognitive Assessment P300 |
| 基金项目:浙江省丽水市科技计划资助项目 |
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| 中文摘要: |
| 摘 要 目的：观察多奈哌齐早期干预老年轻度认知功能障碍患者的疗效及安全性。方法：60例轻度认知功能障碍(MCI)老年患者随机分成治疗组32 例和对照组28例。2组患者均给予控制高危因素(高血压、糖尿病、高血脂等) 治疗。治疗组在此基础上予盐酸多奈哌齐片5 mg，po qd，共12个月。治疗前后分别使用蒙特利尔认知评估量表（MoCA）及认知电位P300评估疗效。结果： 治疗组治疗前后MoCA评分、P300潜伏期和波幅比较，差异有统计学意义(P<0.05)；对照组无明显变化。组间比较，差异有统计学意义(P<0.05)。MoCA量表亚项比较，显示在延迟记忆方面，治疗组治疗前后及与对照组比较，差异均有统计学意义(P<0.05)。结论：多奈哌齐能有效改善老年MCI患者的认知功能。 |
| 英文摘要: |
| ABSTRACT Objective:To Explore the efficacy of early intervention in mild cognitive impairment by donepezil in the elderly.Methods:60 elderly patients with mild cognitive impairment (MCI) were randomly divided into two groups, the treatment group of 32 patients with oral hydrochloride donepezil tablets 5 mg once a day, a total of 12 months and the controlled group of 28 patients. 2 patients were given control of risk factors (hypertension, diabetes, high cholesterol , etc.) treatment . Before and after treatment, Montreal Cognitive Assessment （MoCA）and P300 were used to assess the efficacy. Results:Before and after the treatment , MoCA score and P300 latency and amplitude differences were statistically significant(P<0.05). There was no significant change in the controlled group but the difference between the two groups were statistically significant(P<0.05) . MoCA scale sub item comparison and delayed memory were compared between the two groups before and after treatment. The differences were statistically significant(P<0.05).Conclusion:Donepezil could improve the cognitive function in elderly patients with MCI. |
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