| ABSTRACT Objective:To observe the influence of octreotide on immune function in patients with malignant bowel obstruction. Methods:60 cases of malignant intestinal obstruction patients according to treatment sequence were randomly divided into the treatment group and controlled group (30 cases in each group).The controlled group was given some conventional treatments such as fasting, gastrointestinal decompression, correct water and electrolyte disorders and acid base balance, parenteral nutrition support. The treatment group was given octreotide on the basis of conventional treatment. Their cellular immune indicators CD4+, CD8+ and CD4+/CD8+, humoral immunity indicators IgM, IgA, and IgG and factors of immunomodulatory IL-1, IL-6 and TNF-α were examined before and after treatment. The complication and adverse reactions were observed among the patients of two groups. Results:After the 10d treatment, the CD4+ and CD4+/CD8+ values of the treatment group and IgM, IgA and IgG were higher than those in the controlled group(P<0.05); IL-1, IL-6 but TNF-α concentrations were lower than those of the controlled group(P<0.05). The complication rate of the treatment group was lower than that of the controlled group(P<0.05); No adverse effects were found in the two groups. Conclusion:Octreotide could improve the immune function of the gastrointestinal cancer causing malignant intestinal obstruction and reduce the incidence of complications. |
