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| 铜绿假单胞菌；肺部感染；抗菌药；初始治疗 |
| Pseudomonas aeruginosa；Pulmonary Infection；Antibiotics |
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| DOI： |
| 中文关键词: 铜绿假单胞菌 肺部感染 抗菌药 初始治疗 |
| 英文关键词:Pseudomonas aeruginosa Pulmonary Infection Antibiotics |
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| 中文摘要: |
| 摘 要 目的：回顾分析院内获得性铜绿假单胞菌肺部感染的耐药性及其合理初始治疗的疗效,为临床合理用药提供依据。方法：回顾性分析我院124例铜绿假单胞菌肺部感染患者的痰培养和药敏试验，并比较初始治疗的合理用药与治疗有效率及病死率的关系。结果：药敏试验结果显示对铜绿假单胞菌较为敏感的抗菌药有哌拉西林/他唑巴坦，头孢吡肟，阿米卡星，亚胺培南，头孢哌酮/舒巴坦，头孢他啶。合理初始抗菌药治疗的患者治疗有效率（82.7%），显著高于未接受合理初始治疗的患者（65.3%）（P<0.05）；其病死率（7.7%）低于未接受合理初始治疗者（19.4%）。接受合理初始治疗的患者抗菌药联用对铜绿假单胞菌有效的死亡率显著低于接受单药治疗的患者（P＜0.05）。结论：铜绿假单胞菌肺部感染的初始治疗抗菌药选择要合理，获得药敏试验结果后应根据其结果合理选择抗菌药。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the clinical characteristics and drug resistance of pseudomonas aeruginosa in pulmonary infection and provide guidance for clinical use. Method:124 cases of pulmonary infection caused by pseudomonas aeruginosa were reviewed in our hospital and the Kirby Bauer method was used to detect the susceptibility of pseudomonas aeruginosa. Result:The patients with humoral and local immune dysfunction were susceptible to pseudomonas aeruginosa. Such drugs as tazobactam piperacillin, cefepime, amikacin, imipenem, cefoperazone sulbactam and ceftazidime had lower drug resistance to pseudomonas aeruginosa. The clinical efficacy rate of the patients who received the initial reasonable combined treatment was significantly higher than that of the patients who received the single medication only (P<0.05). Conclusion:A rational choice of antibiotics for the initial treatment of pneumonia infection caused by pseudomonas aeruginosa could not be made until the reception of the drug sensitive test. |
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