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| 肾移植术后糖尿病发病率与危险因素 |
| Study of the Incidence and Risk Factors of Post transplantation Diabetes Mellitus in Renal Allograft Recipients |
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| DOI： |
| 中文关键词: 移植后糖尿病 肾移植患者 发病率 危险因素 |
| 英文关键词:Post transplantation diabetes mellitus Renal allograft recipients Incidence Risk factor |
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| 中文摘要: |
| 摘 要 目的：探讨肾移植术后糖尿病（post transplantation diabetes mellitus, PTDM）的发病率及危险因素。方法：567例术前无糖尿病的肾移植患者入组，回顾性调查患者性别、移植时年龄、体重、体重指数（BMI）、透析时间、移植前空腹血糖等一般临床资料及移植后1，3，6，12，24个月的免疫抑制方案、空腹血糖等实验室检测结果。根据美国糖尿病协会的诊断标准将患者分为PTDM组和对照组（移植后非糖尿病组），采用t检验和χ2检验统计两组间上述各变量的差异，采用logistic回归分析发生PTDM的危险因素。结果：PTDM发病率为24.2%（137/567），男性(OR=1.813, P=0.009)、移植时年龄>45岁(OR=2.528, P<0.001)、移植时体重>65 kg (OR=2.445, P<0.001)、移植时BMI >24 kg·m-2 (OR=1.819, P=0.005)、术后1，3，6，12，24个月的环孢素日剂量及血浓度均与PTDM的发生显著相关。结论：男性、移植时年龄>45岁、体重>65 kg、BMI >24及较高的环孢素日剂量和血浓度是发生PTDM的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective:To study the incidence of post transplantation diabetes mellitus (PTDM) and risk factors of its development. Method:A total of 567 unrelated renal allograft recipients were enrolled in this study. The following variables of the cohort were recorded: gender, age, body mass index (BMI), fasting plasma glucose (FPG) level and dialysis duration before transplantation, immunosuppressive therapy (including agents and plasma levels) , and FPG levels at the time of 1, 3, 6, 12 and 24 months after transplantation. PTDM was defined according to the criteria of the American Diabetes Association. The student's t test and the 2 test were used to compare the variables between PTDM group and Non PTDM group. The logistic regression analyses were used to identify the risk factors of the development of PTDM. Result:Overall PTDM incidence in the population of this study was 24.2%. Male gender(OR=1.813, P=0.009), age>45 years (OR=2.528, P<0.001), body weight >65 kg(OR=2.445, P<0.001), BMI>24 kg·m-2 (OR=1.819, P=0.005) at transplantation, cyclosporine dosages at 1，3，6，12，24 months after transplantation and cyclosporine concentrations at 1，3， 12，24 months after transplantation were associated with the development of PTDM. Conclusion:The older age (>45 years), high body weight ( >65 kg ) and high BMI ( >24 kg·m-2 ) at transplantation, male gender, immunosuppression with high dose and high-concentration cyclosporine were significantly associated with an increased risk of PTDM in Chinese renal allograft recipients. |
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