| ABSTRACT Objective:To analyze reports of antibacterial adverse drug reaction/event(ADR/ADE) reports to understand characteristics and rules of antibiotic ADR/ADE in our hospital and provide the reference for clinical rational drug use. Methods:324 cases of antibacterial drug ADR/ADE reports were collected in our hospital between January 2006 and December 2012 to statistically analyze the clinical manifestations of adverse reactions, route of administration, antibacterial drug types and retrospective causal evaluation.Results: 324 antibacterial drugs ADR reports were more related to women than men; patients from 50 to 87 years old accounted for the highest percent. As for the drug varieties, cephalosporins took the leading position, accounting for 47.53% and were followed by fluoroquinolones, accounting for 29.01%. And as for the administration route, intravenous drip had the largest share in 292 cases, accounting for 90.12%. The front 3 systems and organs involved in by antibacterial adverse drug reactions were mainly the skin and its accessories, the digestive system and the central nervous system. Conclusion:The antibacterial drug classification management should be strengthened and drug indications, strictly controlled to reduce or avoid the occurrence of adverse reactions. |
