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| 小剂量培哚普利吲达帕胺片治疗原发性高血压疗效观察 |
| Observation of Clinical Efficacy of Low dose Perindopril and Indapamide Tablets in the Treatment of Primary Hypertension |
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| DOI： |
| 中文关键词: 培哚普利吲达帕胺片 小剂量 培哚普利 原发性高血压 |
| 英文关键词:Perindopril and indapamide tablets Low-dose Perindopril Primary hypertension |
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| 中文摘要: |
| 摘 要 目的:探讨小剂量培哚普利吲达帕胺片治疗原发性高血压的疗效与安全性。方法：原发性轻中度高血压患者106例分为两组，观察组54例给予培哚普利吲哒帕胺片1片（培哚普利2 mg，吲哒帕胺0.625 mg），qd，对照组52例给予培哚普利片4 mg，qd。治疗8周后，比较两组血压达标率、临床疗效，以及两组不良反应发生情况。结果： 治疗后，观察组总有效率88.8％，对照组总有效率80.7％，两组比较差异无统计学意义(P>0.05)。两组治疗后SBP和DSP均较治疗前明显下降(P<0.05)，且观察组改善效果优于对照组(P<0.05)。观察组不良反应发生率比较，明显低于对照组(P<0.05)。结论：小剂量培哚普利吲达帕胺片治疗原发性高血压可提高血压达标率，降压效果较好，且不良反应少，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective::To discuss the effect of low dose of perindopril and indapamide tablets on antihypertensive effect and safety of patients with essential hypertension.Methods::106 cases of primary mild-to-moderate hypertension patients were divided into observation group(54 cases) and control group (52 cases).They were given perindopril and indapamide tablets(perindopril 2 mg+indapamide 0.625 mg) qd, and perindopril tablets 4 mg qd,respectively.8 weeks after the continuous treatment,their hypertension effective rate,treatment effect and adverse reactions were observed. Results:: After the treatment,the total effective rate of the observation group was 88.8%,and the total effective rate of the control group was up to 80.7%.There were no statistically significant difference (P>0.05) between the two groups.The diastolic blood pressure(DBP) and SBP more obviously declined after the treatment than before it and the effect of the observation group was significantly better than that of the control group(P<0.05).The total adverse reaction of the observation group was oboviously lower than that of the control group(P<0.05). Conclusion:: Low dose perindopril and indapamide tablets had its good decompression effect on the treatment of primary hypertension, but fewer side effects.It could improve the blood pressure and tolerance at the same time; therefor,it is worth of clinical application. |
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