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| 鼠神经生长因子治疗三叉神经半月节微球囊压迫术后面部麻木观察 |
| Efficacy and Safety of Mouse Nerve Growth Factor for Trigeminal Facial Numbness after Micro balloon Compression |
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| DOI： |
| 中文关键词: 三叉神经痛 面部麻木 微球囊压迫术 鼠神经生长因子 |
| 英文关键词:Trigeminal neuralgia Facial numbness Micro balloon compressure Mouse nerve growth factor |
| 基金项目:杭州市科技局课题（编号：20110833B04） |
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| 中文摘要: |
| 摘 要 目的:观察鼠神经生长因子对三叉神经半月节微球囊压迫术后面部麻木的疗效及安全性。方法：原发性三叉神经痛患者204例，经三叉神经半月节微球囊压迫术治疗后随机分为观察组和对照组各102例。对照组术后给予维生素B1注射液0.1 g，im qd，维生素B12注射液0.5 mg，im qd。观察组在对照组基础上加用鼠神经生长因子30 μg，im qd，治疗3周后比较两组疗效和安全性。结果：两组患者术后疼痛即刻缓解率均为100%。观察组总有效率90.2%，显著高于对照组的76.5%，差异有统计学意义（P<0.01）。两组均未发生药品不良反应。结论：鼠神经生长因子可显著提高三叉神经半月节微球囊压迫术后面部麻木的疗效，安全性好，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the efficacy and safety of mouse nerve growth factor for trigeminal facial numbness after micro balloon compression. Methods:Two hundred and four cases of patients with primary trigeminal neuralgia treated by micro balloon compression were randomly divided into two groups, and 102 cases in each group. Control group were given vitamin B1 injection0.1g,imqd , vitamin B12 injection 0.5mg,im qd, duration of 3 weeks. Observed group were given nerve growth factor from rats 30 μg im qd duration of 3 weeks. The efficacy and safety of the two groups were compared. Results:Immediate remission rate of postoperative pain in both groups were 100%. The total efficacy rate of the observation group were90.2%, significantly higher than the control group of 76.5%(P<0.01). Both groups were no pain at the injection site and adverse drug reactions. Conclusion:the mouse nerve growth factor can significantly increase efficacy for numbness after balloon compression and it is worth advertising. |
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