| ABSTRACT Objective::To discuss the protection effect of octreotide on intestinal mucosal barrier function of acute pancreatitis (AP) patients. Methods:64 cases of acute pancreatitis (AP) patients were randomly divided into octreotide group and controlled group. The patients in the two groups were given symptomatic treatment like fasting and water deprivation, gastrointestinal decompression, antispasmodic and analgesic, infection prevention (IP), parenteral nutritional support, etc. The patients in octreotide group were given octreotide (100 μg) by subcutaneous injection once every 8 hours for 1 week, and the patients in the controlled group were given the same medical treatment except octreotide. The changes of toxin, D lactic acid, and TNF α in the serum of the patients in the two groups were observed before and after medical treatment.Results:After 1 week’s medical treatment, toxin, D lactic acid, and TNF α levels in the serum of the patients in the two groups declined more obviously than before (P<0.05 or P<0.01), and the declining rate in octreotide group was much higher than that in the controlled group (P<0.05); meanwhile, the total curative efficiency in octreotide group was much higher than that in the controlled group. 2 or 5 cases of ADRs appeared in the control group and octreotide group during the medical treatment with no statistical differences after comparison (P>0.05). Conclusion:Octreotide had its reliable effect on acute pancreatitis (AP), especially in mild case patients, whose mechanism of action had close effect on lowering the toxin, D lactic acid and TNF α levels in serum, and protecting the function of intestinal mucosal barrier. |
