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荆门地区1 814例药品不良反应报告分析
Analysis of 1 814 Cases of Adverse Drug Reaction in Jingmen Area
  
DOI:
中文关键词:  药品不良反应  报告  监测  合理用药
英文关键词:Adverse drug reaction  Reports  Monitoring  Rational drug use
基金项目:
作者单位
胡耀梅 荆门市第一人民医院药学部(湖北荆门 448000) 
邵寅 荆门市第一人民医院药学部(湖北荆门 448000) 
蔡小曼 湖北医药学院药学系 
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中文摘要:
      摘 要 目的:分析湖北省荆门地区药品不良反应(ADR)发生的特点,为促进临床安全用药提供参考。方法: 查阅荆门地区2012年上报国家药品不良反应监测中心的1 814份ADR报告,分别按报告单位、患者性别、药品种类、剂型、给药途径、ADR累及器官及系统等项目统计并分析。结果:1 814例报告中,来自医疗机构的报告占99.78%;ADR患者男女比例相当;引起ADR的药物以抗菌药多见,占59.59%,其中以β-内酰胺类构成比最高,占52.98%;引起ADR的给药途径以静滴多见,占78.78%;ADR累及以消化系统、皮肤及附件多见,分别占34.43%、32.12%。结论:各报告单位要重视ADR监测,不断提高ADR监测水平,降低ADR的发生风险。
英文摘要:
      ABSTRACT Objective::To analyze the characteristics of adverse drug reaction (ADR) in Jingmen area of Hubei province and promote clinical rational drug use. Methods:The report units, sex of the patients, types of ADR, drug varieties and result evaluation were analyzed from 1 814 ADR reports in Jingmen area. Results:99.78% of the cases came from the medical institutions, the ratio of male to female was almost equal,ADRs were mainly caused by antibiotics(59.59%), and among the antibiotics the percent of 52.98 cases were caused by β-lactum. The main route of administration was caused by intravenous drip(78.78%), main clinical manifestations of ADRs were lesion of skin and its appendants, and digestive system accounting for 34.43% and 32.12%, respectively. Conclusion:Reporting institutions should pay attention to the monitoring of ADR, improve their monitoring level and reduce the risks of ADR occurrence.
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