| ABSTRACT Objective::To analyze the distribution and changes in drug resistance of pathogens causing respiratory tract infections in pediatrics department to provide the evidence for clinical treatment. Methods:Pathogens in sputum were isolated, strains were identified with Vitek2-Compact system, the drug sensitivity was performed with the disc diffusion method(K-B law), and the drug resistance of pathogens was analyzed.Results: 1 005 strains of pathogens were isolated from 2 814 sputum samples from 2010 to 2012. Three hundred and thirty-five of the stains were gram-positive bacteria. The most strains isolated was staphylococcus aureus, followed by staphylococcus epidermidis and streptococcus pneumoniae; 625 stains were gram-negative bacteria. The most strains isolated was haemophilus influenzae, followed by klebsiella pneumoniae, haemophilus parainfluenzae, escherichia coli and moraxelle catarrhalis. 45 srains were fungus，and the most strains isolated was Candida albicans,followed by Candida tropicalis. Staphylococcus had its high resistance to benzylpenicillin and erythromycin, and streptococcus pneumoniae had its high resistance to erythromycin and trimethoprim-sulfamethoxazole. The resistance rate of klebsiella pneumoniae and escherichia coli cephalosporins was almost 60%. Haemophilus was resistant to ampicillin, azithromycin and trimethoprim sulfamethoxazole in different degree. Moraxelle catarrhalis had its high resistance to benzylpenicillin and ampicillin. Conclusion:The bacteria isolated from the Pediatrics Department were mainly gram negative bacteria, different bacteria had their different resistance to antibiotics, the sputum sample should be tested in time and clinicians should choose correct antibiotics according to the pathogens distribution and drug resistance test. |
