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| 更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎的疗效观察 |
| Curative Effect of Ganciclovir Ophthalmic Gel on Herpes Simplex Keratitis |
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| DOI： |
| 中文关键词: 单纯疱疹病毒性角膜炎 更昔洛韦眼用凝胶 疗效 复发 |
| 英文关键词:Herpes simplex keratitis Ganciclovir ophthalmic gel Curative effect Reoccurrence |
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| 中文摘要: |
| 摘 要 目的:探讨更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎(HSK)的疗效及预防复发的作用。方法： HSK患者64例随机分为更昔洛韦组与对照组各32例。更昔洛韦组予0.15%更昔洛韦眼用凝胶和0.3%氧氟沙星眼液交替滴眼，qid。对照组予0.1%阿昔洛韦滴眼液和0.3%氧氟沙星眼液交替滴眼，qid。两组疗程均为3周。观察两组患者治疗后临床疗效和不良反应，并随访观察治疗后2年内的复发率。结果：治疗3周后，更昔洛韦组临床总有效率明显高于对照组(P<0.05)。两组分别出现不良反应3例和5例，不良反应发生率比较，差异无统计学意义(P>0.05)。治疗后随访2年，观察组患者复发率明显低于对照组(P<0.05)。结论：更昔洛韦眼用凝胶治疗HSK疗效确切，安全性较好，能减少其复发率，具有治疗和预防HSK复发的作用。 |
| 英文摘要: |
| ABSTRACT Objective::To discuss the curative effect of ganciclovir ophthalmic gel on herpes simplex keratitis (HSK). Methods:64 cases of patients with HSK were divided into ganciclovir group and controlled group at random, with 32 cases in either group. The patients in ganciclovir group were given 0.15% ganciclovir ophthalmic gel and 0.3% ofloxacin eye drops dropped into eyes alternatively, qid. The patients in the controlled group were given 0.1% aciclovir eye drops and 0.3% ofloxacin eye drops dropped into eyes alternatively, qid. The courses of the treatment in both groups were 3 weeks. The clinical curative effect and untoward effect of patients in the two groups were observed before and after medical treatment, and reoccurrence rates were followed-up as well within 2 years after the medical treatment. Results:After 3 weeks’ medical treatment, the total clinical efficiency in ganciclovir group was much higher than that in the controlled group(P<0.05). 3 or 5 cases of untoward effect appeared in the two groups ［(9.38%) and (15.63%)］. After the occurrence rates of adverse drug reaction were compared, no statistical differences appeared (P>0.05). According to 2 years' following up after the medical treatment, the reoccurrence rate of patients in the observation group was much lower than that in the controlled group (P<0.05).Conclusion:Ganciclovir ophthalmic gel had its reliable curative effect on HSK with high security, which could reduce the reoccurrence rate and have the treatment and preventive function on HSK. |
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