| ABSTRACT Objective::To study the leucocytopenia induced by antidepressants in the depressive inpatients.Methods:From the hospital information system, the author screened out he inpatients in 2012 who were diagnosised as depression and took leucocyte increasing agents during their hospitalization, and then recorded their white blood cells and neutrophils values on admission and after antidepressants treatment, antidepressants and leucocyte increasing agents, and time when the patients developed the leucocytopenia and the prognosis. But those with leucocytopenia and hematological diseases on admission were excluded. Methods:30 of the 735 depressived inpatientspatients (4.1%) developed leucocytopenia after taking antidepressants and at the same time neutropenia1 emerged simultaneously in 6 patients. Their white blood cells values were from 3.3×109·L-1 to 4.0×109·L-1. The range of the days when patients were found leucocytopenia after receiving their antidepressants treatment were from 7 to 31. The mean value was（16.6±7.7）days. The front three antidepressants inducing leucocytopenia were escitalopram, venlafaxine and paroxetine. Most patients' white blood cell values could recover to the nomal values after they received the leucocyte increasing agents. Conclusion:The antidepressants could cause the mild and moderate leucocytopenia, most of which could restore to normal after therapy; therefore, it is necessary to regularly monitor the hemogram, discern suspected drugs and provide symptomatic treatment during the antidepressant treatment. |
