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| 托拉塞米联合甘露醇治疗脑出血临床疗效观察 |
| Clinical Efficacy of Torasemide Combined with Mannitol in the Treatment of Cerebral Hemorrhage |
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| DOI： |
| 中文关键词: 托拉塞米 甘露醇 脑出血 肾功能损害 |
| 英文关键词:Torasemide Mannitol Cerebral hemorrhage Renal function damage |
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| 中文摘要: |
| 摘 要 目的:观察托拉塞米联合甘露醇治疗脑出血的临床疗效和安全性。方法：60例脑出血住院患者随机分为两组各30例。观察组交替应用托拉塞米与小剂量20%甘露醇注射液；对照组单用 20%甘露醇注射液。治疗1周后比较两组疗效及患者血清BUN、CR水平变化。结果：观察组总有效率为80.0%，与对照组比较差异无统计学意义（P>0.05）。观察组治疗前后血清BUN、CR水平无明显变化（P> 0.05），而对照组治疗后血清BUN、CR水平明显较前升高（P<0.05）。结论：与使用大剂量甘露醇治疗相比，小剂量甘露醇与托拉塞米交替应用同样能达到减轻脑水肿和降低颅内压的治疗效果，且对肾功能的损害明显降低，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective::To observe the clinical efficacy and safety of torasemide combined with mannitol in the treatment of cerebral hemorrhage. Methods:60 cases with cerebral hemorrhage were assigned randomly to two groups with 30 cases in either group. The observation group were treated with torasemide and low dose mannitol alternately and the control group, treated with 20% mannitol only. 1 week after, the curative effect and serum BUN and CR of the two groups were observed. Results: There was no significant difference between them in the overall curative effect（P>0.05）. The observation group had no obvious change in serum BUN and CR before and after the treatment （P>0.05），while the serum BUN and CR of the control group increased significantly（P<0.05）.Conclusion:In terms of high dose mannitol, the application of low dose mannitol and torasemide could also achieve the therapeutic effect of relieving the cerebral edema and reducing the intracranial pressure rapidly, while an alternate application of low dose mannitol and torasemide could significantly decrease the damage of the renal function. Therefore the treatment was worthy of clinical popularization and application. |
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