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| 吗替麦考酚酯联合泼尼松治疗老年难治性肾病综合征观察 |
| Clinical Observation of Mycophenolate Mofetil Combined with Prednisone in the Treatement of Refractory Nephrotic Syndrome in Aged People |
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| DOI： |
| 中文关键词: 吗替麦考酚酯 环磷酰胺 泼尼松 老年 难治性肾病综合征 |
| 英文关键词:Mycophenolate mofetil Cyclophosphamids Prednisone Aged people Refractory nephrotic syndrome |
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| 中文摘要: |
| 摘 要 目的:观察吗替麦考酚酯治疗老年难治性肾病综合征的疗效及安全性。方法： 老年难治性肾病综合征患者69例随机分为观察组和对照组。在口服泼尼松0.5 mg·kg-1·d-1治疗基础上，观察组联用吗替麦考酚酯，对照组联用环磷酰胺，进行1年的随访。观察两组患者治疗前，治疗后6、12个月时24 h尿蛋白定量、血清白蛋白、血肌酐的变化情况，并记录两组药品不良反应发生情况。结果：治疗12月后，吗替麦考酚酯组24 h尿蛋白定量较环磷酰胺组明显下降（P=0.021）、血清白蛋白明显升高（P=0.039）。治疗12月后，吗替麦考酚酯组总有效率为77.14%；环磷酰胺组总有效率为52.94%。吗替麦考酚酯组较环磷酰胺组疗效明显（P=0.041）。结论：吗替麦考酚酯联合小剂量激素可有效治疗老年难治性肾病综合征，且不良反应小。 |
| 英文摘要: |
| ABSTRACT Objective::To observe the efficacy and safety of mycophenolate mofetil combined with prednisone in the treatment of refractory nephrotic syndrome in aged people. Methods:69 patients with refractory nephrotic syndrome were randomly divided into the observation group and control group. The control group were given prednisone and cyclophosphamids. The observation group were given prednisone and mycophenolate mofetil, the treatments were maintained for 12 months and the changes of clinical indicators and adverse reactions were recorded in 6 and 12 months of the treatment. Results: 12 months after the treatment, the levels of 24h urinary protein excretion more obviously decreased（P=0.021) in mycophenolate mofetil group and than in cyclophosphamids group, levels of the serum albumin more obviously increased than those of the control group, and the levels of renal function more obviously decreased（P=0.039）. The total effective rate of mycophenolate mofetil group(77.14%)was significantly higher than that of cyclophosphamids group(52.94%).（P=0.041）. Conclusion:Mycophenolate mofetil was an effective and safe drug in the treatment of refractory nephrotic syndrome in aged people. |
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