|
| 药物致5-羟色胺综合征1例报告及文献分析 |
| One Case Report of Drug Caused Serotonin Syndrome and its Literature Analysis |
| |
| DOI： |
| 中文关键词: 5-羟色胺能药物 5-羟色胺综合征 药物不良反应 |
| 英文关键词:Serotonin to drugs Serotonin syndrome Case report Literature analysis |
| 基金项目: |
|
| 摘要点击次数: 1168 |
| 全文下载次数: 1260 |
| 中文摘要: |
| 摘 要 目的:探讨药物致5-羟色胺综合征的临床特点及原因，为临床合理用药提供参考。方法： 报道我院1例疑似氟西汀致5-羟色胺综合征的病历，并通过检索1994～2013年国内医药期刊报道的相关文献进行统计和分析。结果：文献报道以及我院氟西汀致可疑5-羟色胺综合征共40例，其中14例是单用一种药物引起的，其余26例都是联合用药引起。5-羟色胺综合征大部分发生在用药24 h内（42.5%）。经停药及对症治疗后大部分病例（95%）症状缓解。结论：药物引起5-羟色胺综合征时有发生，临床应用时应密切关注患者的变化，以减少不良反应的发生。 |
| 英文摘要: |
| ABSTRACT Objective:: To investigate the clinical characteristics and causes of serotonin syndrome induced by drugs to provide reference for rational drug use in clinical practice. Methods:1 case of suspected fluoxetine induced serotonin syndrome in our hospital was reported, and relevant literature published in domestic medical journals through 1994 ~2013 were retrieved and statistically analyzed. Results:According to reports in the literature and case in our hospital, a total of 40 patients were collected. 14 cases were induced by a single drug use and the rest 26 cases were caused by combined use of drugs. The serotonin syndrome occurred in 42.5% of the patients within 24hrs administration. The symptoms were relieved in 95% of the patients after drug withdrawal and symptomatic treatment. Conclusion:Drug induced serotonin syndrome occurred occasionally, and safety monitoring should be carried out in patients during the application of drugs to reduce the incidence of ADR. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
