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| 鼠神经生长因子早期干预治疗外伤性癫痫观察 |
| Observation of the Early Interventional Treatment of Traumatic Epilepsy with Mouse Nerve Growth Factor |
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| DOI： |
| 中文关键词: 鼠神经生长因子 外伤性癫痫 丙戊酸钠 |
| 英文关键词:Rat nerve growth factor Traumatic epilepsy Sodium valproate |
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| 中文摘要: |
| 摘 要 目的:探讨鼠神经生长因子早期干预治疗外伤性癫痫的临床疗效。方法： 100例外伤性癫痫患者随机分为两组，对照组50例患者常规给予口服丙戊酸钠片0.2～0.4 g，tid，连续1年；观察组在对照组治疗基础上加用鼠神经生长因子肌注，30 μg·d-1，连续治疗3周。两组均观察及随访1年后评价疗效，比较两组癫痫发作次数和发作时间。结果：观察组总有效率90％，对照组总有效率72％。两组差异有统计学意义（P＜0.05）。治疗后，观察组及对照组癫痫发作次数及持续时间均明显减少（P＜0.01），而观察组癫痫发作次数及持续时间较对照组减少更为显著（P＜0.05）。结论：早期应用鼠神经生长因子干预治疗外伤性癫痫，能显著减少癫痫发作次数，疗效可靠。 |
| 英文摘要: |
| ABSTRACT Objective::To explore the clinical effect of early interventional treatment of traumatic epilepsymouse with nerve growth factor.Methods:100 cases of traumatic epilepsy patients were randomly divided into two groups, 50 cases in the control group were given oral sodium valproate tablets 0.2-0.4g, TID, for 1 consecutive years and the observation group were given the injection of mouse nerve growth factor, 30 μg·d-1, for 3 consecutive weeks based on the treament of the control group. The two groups were observed and followed up to evaluate their efficacy after 1 year. The number of seizures and seizure time of the two groups were compared. Results: In the observation group, the total effectiveness was 90% and the comparison group total effectiveness was 72%. There was significant difference between the two groups (P<0.05). After treatment, the seizure frequency and duration were significantly reduced in the observation group and the control group（P＜0.01），but the seizure frequency and duration was more significantly reduced in the observation group than in the control group (P<0.05). Conclusion:The early application of nerve growth factor intervention in the treatment of traumatic epilepsy could significantly reduce the number of seizures, the curative effect is reliable. |
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