| ABSTRACT Objective:: To investigate the distribution of pathogen, change of bacterial resistance and utilization of antibacterial drugs in hospitalized patients of our hospital from 2010 2012 to provide reference for clinical reasonable application of antibiotics. Methods:The common pathogenic bacteria and resistance rate data collected from the clinical isolattion in 3 years were statistically analysed. According to the drug management records from the hospital pharmacy in 3 years, the antibacterial frequency of use (DDDs) was calculated. Results:A total of 18 177 strains of pathogens were isolated. Among them, 6 species of Gram negative bacteria and 4 species of Gram positive strains accounted for 54.77% and 19.09%. The detection rates of MRSA and MRSCN of staphylococcus in 3 years were 53.05%, 47.32%, 53.55% and 80.64%, 83.04%, 83.29%, and the detection rates of Escherichia coli, Klebsiella pneumoniae producing extended spectrum β lactamases (ESBLs) in 3 years were 63.34%, 54.80％,38.00％ and 43.52%,35.30%,35.00% respectively. The resistance rate of staphylococcus and E. faecium and E. faecalis to glycopeptide antibiotic was less than 6% in 3 years. The drug susceptibility rate of enterobacteriaceae to carbapenems was higher, and the resistance rate was less than 20% , but showed an upward trend year by year. The non fermentative bacteria pseudomonas aeruginosa and acinetobacter baumannii presented high resistance rate to various antibiotics, and their resistance rates were between 20% 30% and 30% 45% respectively to carbapenems. The top two antibiotics in the list of DDDs were always cephalosporins and penicillins, the third were quinolones, nitroimidazole and macrolide antibiotics, respectively. Antimicrobial total DDDs decreased year by year and had a certain relationship between resistance of some bacteria and their antibiotic DDDs. Conclusion:We should strictly implement the Guiding Principles for Clinical application of antibacterial, strengthen the surveillance of bacterial resistance and reasonable application management of antibiotics, and restrict the utilization of broad spectrum antibiotics to postpone bacterial resistance. |
