| ABSTRACT Objective::To compare the efficacy and safety of the short treatment with gefarnate and gefarnate in combination with esomeprazole and the long treatment with gefarnate and esomeprazole alone to prevent patients’ ulcers and bleeding due to the use of low-dose aspirin. Methods: 123 cases of patients were selected to take low-dose aspirin to treat their peptic ulcer bleeding. 6-8 weeks after the treatment of ulcer healing according to their admission order, they were divided into Group A (gefarnate 100mg, po tid, long term use) and Group B (esomeprazole 20mg, po qd, long term use) and Group C (gefarnate 100mg, po tid, long term use + esomeprazole 20mg, po qd, taking 8 weeks). Their incidence of bleeding and incidence of adverse reactions were compared in the periods of 0-8 and 9-50 weeks.8 weeks after the treatment the incidence of their rebleeding was 34.2% for Group A, 17.5% for Group B and 2.2% for Group C with significant difference(P＜0.05). Its incidence of rebleeding was obviously lower than that of Groups A and B. 50 weeks after the treatment, the incidence of bleeding respectively was 15.8% for Group A , 10% for Group B and 11.1% for Group C. There were not any significant differences(P＞0.05) in the three groups. Conclusion:After the short term treatment with esomeprazole in combination with gefarnate, the maintenance treatment methods with gefarnate could achieve the same therapeutic effect as PPI(proton pump inhibitors) on the prevention and treatment of ulcers and bleeding due to low-dose aspirin, and could also reduced the complications caused by the long use of PPI . |
