| ABSTRACTIncretin drugs include GLP 1 receptor agonists and DPP 4 inhibitors. The research and clinical application for these drugs have been made rapid progresses in recent years because of their unique mechanism of action differing from other traditional anti diabetic drugs. However, GLP 1 receptors express in many tissues, and DPP 4 substrates are numerous. Long term use of incretin drugs maybe has safety risk. In this paper，we reviewed and analyzed the reverse effects of incretin drugs on pancreas, thyroid, cardiovascular system, digestive system, etc. The result showed that the pancreatitis and tumor were the biggest concern at present clinical. Therefore, it is necessary for us to pay long term attention to the use of the incretin drugs, provide safety data for their clinical application. |
