| ABSTRACT This article aims to review the relationship between aromatic antiepileptic drugs (AEDs) induced cutaneous adverse drug reactions (cADRs) and HLA genes polypeptide in different national or ethnic groups to provide an information service for the rational use, risk management and individualized medication of AEDs. Through the inclusion and exclusion criteria, 32 closely related articles published during year 2004 2013 in English and Chinese were collected by the online search through 8 key words. The findings of these studies with heterogeneity were pooled and analyzed and the advances of researches in related field were systematically reviewed. The studies found the relativity between Asian, European HLA genes with AEDs induced cADRs: 1.HLA-B*1502 gene in parts of Asia and the Han population ( except in Japan, Korea ) was strongly correlated with SJS/TEN which belonged to carbamazepine (CBZ)-cADRs, but not correlated with CBZ-HSS/MPE; 2. The relationship between HLA-B*1502 gene and other aromatic AEDs causing SJS/TEN was uncertain; 3.HLA-B*1511 gene had some relation with CBZ SJS/TEN occurrence in Japanese and Korean people; 4.HLA-A*3101 gene and various types of CBZ induced cADRs in Europe, Japan, South Korea were closely related; 5.Cost benefit analysis of HLA-B*1502 genetic screening were different from disparate populations and races; 6. The pharmacological mechanism of HLA-B*1502 gene in severe cADRs remained unclear. As a conclusion , before treatment with CBZ, Asians (except Japan, Korea) required HLA-B*1502 genetic screening, while the Japanese, Koreans needed to detect their HLA-B*1511 gene. This way, serious ADRs could be effectively avoided in using CBZ and risks of its medication and economic losses could be prevented . |
