| ABSTRACT Objective:To observe curative effect and security of montelukast combined with ketotifen on children with cough variant asthma. Methods:80 cases of children with cough variant asthma were divided into experimental group and control group at random. The children in two groups were given Terbutaline by spray inhalation 5mg per time twice a day, which shall be stopped after the acute stage, and were given ketotifen through the mouth 0.5-1mg per time twice a day for 4 weeks. The children in experimental group were given montelukast dulcet 2.5-5mg per time once a day for 4 weeks. The clinical symptom relief and transference cure times,the lung function improvement condition of children in two groups were observed, and the treatment curative effect and security was evaluated as well. Results:After the medical treatment, clinical symptom relief and transference cure times of children in experimental group were both shorter than those in control group (P<0.05). After comparing lung function of children in two groups before the medical treatment, no obvious statistical difference appeared (P>0.05). After 4 weeks’ medical treatment, lung function of children in two groups was improved than before (P<0.05 orP<0.01), and the improvement rate of children in experimental group was much higher than that in control group (P<0.05 orP<0.01). Meanwhile, total efficiency of children in experimental group was much higher than that in control group. No adverse drug reactions appeared in children in two groups after the medical treatment. Conclusion:montelukast combined with ketotifen had reliable curative effect on relieving the clinical symptom, and improving lung function with high security of children with cough variant asthma. |
