| ABSTRACT Objective:To investigate the clinical distribution and changes of antimicrobial resistance of Staphylococcus aureus (SAU) isolated from the hospitalized patients and analyse the influence of special rectification activities of antibacterial on clinical use of antibacterials so as to provide the clinical reasonable medication. Methods: A retrospective analysis was performed for the clinical distribution and antimicrobial resistance of 693 strains of SAU from 2007 to 2013. Results:There were 65.8%people above 50 years old among the SAU, were mainly isolated from the wound secretions, sputum and urine specimens, isolation rate was relatively high in orthopedic, general surgery department. Since 2007 the drug resistance rate to penicillin and chloramphenicol had risen from 25.7% to95.9%. The drug resistance rate to erythromycin, clarithromycin and rifampicin reached the highest point in 2011 and had a statistically significant decline between 2012 and 2013. No vancomycin and linezolid resistant strains detected, the drug resistant rate to quinupristin dalfopristin, nitrofurantoin and trimethoprim/sulfamethoxazole were lower than 30%, and the drug resistance rate to penicillin was 95.0%, and the drug resistance rate to clarithromycin was 80.0%. Meticillin resistant Staphylococcus aureus (MRSA) was between 13.9% and 42.9% in the last seven years. The drug resistance rate of MRSA to 9 different antibiotics like oxacillin, erythromycin and clarithromycin were higher than those of the methicillin sensitive Staphylococcus aureus(MSSA), the drug resistance rate of MRSA to trimethoprim/sulfamethoxazole was lower than MSSA(P<0.01). Conclusion: Compared with other medical organizations, the drug resistance of SAU in our hospital was well controlled. The special rectification activity of antimicrobial agents between 2011 and 2013 has paid off. There was a great variety of products for you to choose . |
