| ABSTRACT Objective:To observe the clinical efficacy and safety of risperidone combined sertraline in the treatment of patients with schizophrenia with obsessive compulsive symptoms.Methods: 60 patients of schizophrenia with obsessive compulsion symptoms were randomly divided into two groups, 30 cases in each group.The control group are treated with risperidone tablets oral therapy, the observation group with treated with sertraline on the basic of the control group, two groups were observed 8 weeks. The positive and negative symptoms scale were used to assess mental symptoms, Yale Brown obsessional compulsive symptoms scale were used to evaluate forced symptoms, side effects scale were used to assess adverse reactions respectively before and during treatment. Results: After treatment，the total efficiency rate of psychiatric symptoms improvement on the two groups had no significant difference(P＞0.05), but the total effective rate of forced symptoms improvement on observation group was significantly higher than control group (P<0.01).Treatment after the 4 and 8 weekend, the observation group, total score of PANSS, Y-BOCS score, forced thinking dimension, compulsive behavior dimension classification than before treatment was significantly decreased (P<0.05 or P<0.01); control group at 4 and 8 weekend PANSS total score, scores of Y-BOCS, forced thinking dimensions were randomly assigned to treatment significantly decreased (P<0.05 or P<0.01), at the end of the 8th week, forcing behavior dimension points compared with before treatment, decreased significantly (P<0.05). After treatment, the total score of Y-BOCS, obsessive compulsive thinking and compulsive behavior were statistically significant (P<0.05 or 0.01). The scores of TESS in the 8 groups at the weekend of two were not statistically significant (P＞0.05).There was no significant difference on the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Risperidone combined sertraline in the treatment of schizophrenia patients with obsessive compulsive symptoms has significant effect and high safety, significantly better than that of risperidone therapy only. |
