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367株嗜麦芽窄食单胞菌耐药性分析
Analysis of the Distribution of 367 Strains of Stenotropomonas maltophilia and its Drug Resistance
  
DOI:
中文关键词:  嗜麦芽窄食单胞菌  耐药性  院内感染  抗菌药
英文关键词:Stenotropomonas maltophilia  Drug resistance  Nosocomial infection  Antibiotics
基金项目:
作者单位
吴大盈 丽水市中心医院心血管内科(浙江丽水 323000) 
朱延焱 丽水市中心医院药剂科 
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中文摘要:
      摘 要 目的:分析丽水市中心医院嗜麦芽窄食单胞菌的来源、病区分布及耐药情况,为临床合理使用抗菌药提供依据。方法:收集分离自2009年1月~2012年12月的367株嗜麦芽窄食单胞菌,采用法国梅里埃Vitek2-Compact全自动细菌分析仪鉴定细菌,用K-B纸片扩散法进行药敏试验。结果:嗜麦芽窄食单胞菌主要来源于痰液标本,占86.6%,临床分布以ICU最高,占38.4%,对抗菌药米诺环素、左氧氟沙星、复方磺胺甲噁唑、头孢哌酮/舒巴坦的耐药率分别为6.6%,8.8%,10.4%和9.8%。结论:嗜麦芽窄食单胞菌主要分离自ICU、神经外科和呼吸内科的呼吸道标本中,该菌对多数抗菌药有固有耐药,但对米诺环素、左氧氟沙星、复方磺胺甲噁唑和头孢哌酮/舒巴坦的耐药率较低,临床应根据药敏结果合理选用抗菌药。
英文摘要:
      ABSTRACT Objective: To provide basis for clinical rational use of antibacterial by studying the source, distribution and drug resistance of Stenotropomonas maltophilia in Lishui Central Hospital. Methods:367 strains of S. maltophilia were collected from January 20009 to December 2012. Identified the bacteria strains with VITEK 2 COMPACT instrument.And the drug resistance test adapted K-B test.Results: S.maltophilia were mainly isolated from sputum sample, accounting for 86.6%. The clinical distribution of ICU was the highest in the hospital,accounted for 38.4%. The resistance rate of S.maltophiliato minocycline, levofloxacin, trimethoprim sulfamethoxazole and cefoperazone/sulbactam were 6.6%,8.8%,10.4% and 9.8%. Conclusion:The S.maltophilia were mainly isolated from specimen of sputum in ICU, neurosurgery department and respiratory medicine department. The organism was inherently resistant to most antibacterial agents, but less resistant to minocycline, levofloxacin、trimethoprim sulfamethoxazole and cefoperazone sulbactam.The clinician should choose suitable antibiotics based on the results of drug sensitivity tests.
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