| ABSTRACT Objective:To analysis the instructions of national immunization program vaccines and to research the possible improvements. Methods:10 vaccines which used for the national routine immunization including 37 instructions were collected, and then analyzed using with cluster analysis. All these instructions approval or amendment date are in the Pharmacopoeia of People's Republic of China in 2010 edition (3rd). Results:The 37 instructions of national immunization program vaccines came from 17 vaccine manufactures. There were 17 instructions of attenuated live vaccine, 5 instructions of inactivated vaccine, 3 instructions of gene vaccine and 12 instructions of toxoid vaccine. Fever, acute/severe chronic disease and acute exacerbation of chronic disease, untreated epilepsy and brain disease and anaphylactic reaction to previous dose of vaccine were considered to be a contraindication in all of the vaccine instructions. Cluster analysis showed that different types of vaccine contraindication were classified not clear. Conclusion:Recommended that vaccine manufactures draft vaccine contraindications should be detailed, clear notes related the content, different types of vaccine contraindications should have its own characteristics, and vague description of vaccine contraindications should be eliminated. |
