| ABSTRACT Objective:To investigate the occurrence, characteristics and related factors of adverse drug reactions(ADR) in our hospital, so as to promote the rational using of drug in clinic. Methods:During the period from 2012 February to 2014 February, 188 ADR were reported to the National Center for ADR monitoring network platform in our hospital. These data were classified and analyzed statistically in relevant factors. Results:The report showed that the majority of the 188 cases are patient who over 61 years old(35.64%); the incidence of ADR was higher in women with the ratio of male to female was 0.79∶1; in the related drugs, antimicrobial drugs, traditional Chinese medicine preparation, circulation system drugs, vitamins and nutrition preparations had higher rates of ADR. In the clinical manifestations of ADR ,the lesions of skin and its adnexa was most(42.55%), followed by the digestive system, circulatory system and nervous system. Intravenous drip caused the highest percentage of ADR, followed by oral administration. The new and serious ADR were 28 cases, accounting for 14.89% of the total number of ADR.In our hospital, ADR reporting rate was low, because some cases were missing; The number of new, serious ADR was less. 8 cases of serious adverse reactions had obviously irrational usage of drug. Conclusion:ADR monitoring and reporting should be strengthened. The work on the ADR knowledge propagate shall be properly done. The supervision and monitoring should be pay more attention to the special groups, intravenous administration and intensive safety monitoring varieties. Strengthen the national “adverse drug reaction reporting of information” to improve the level of rational drug using, and reduce the incidence of ADR,especially the repeated occurrence of serious ADR. |
