| ABSTRACT Objective:To review the effects of hemocoagulase agkistrodon (HCA) for hemostasis in surgical tresis vulnus. Methods: Databases including PubMed, CBM, CNKI, VIP and Wanfang were searched electronically to collect literature published. Randomized controlled trials(RCTs) were identified about HCA for hemostasis in surgical tresis vulnus. References of the included studies were also retrieved. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assess the quality of the included studies. Then Meta-analysis was performed using RevMan 5.2 software. Results:Fourteen trials involved 1 382 patients were included. The results of Meta-analysis indicated that, using HCA for hemorrhagic volume in surgical tresis vulnus[MD=-1.67, 95%CI（-2.04，-1.30）, P<0.000 1]，drainage volume after the operation[MD=-19.10, 95%CI（-25.96，-12.25）, P<0.000 01], hemorrhagic volume per square unit[MD=-0.05, 95%CI（-0.08，-0.03）, P<0.000 01] significantly decreased in comprison with blank control, hemostatic time[MD=-50.67, 95%CI (-74.85, -26.49), P<0.000 1]were significantly shorten with blank control. Conclusion:HCA administered preoperatively could significant reduce the hemorrhagic volume, drainage volume after the operation, hemorrhagic volume per square unit and shorten hemostatic time compared with blank control in surgical patients. However, due to limitations of the included studies, the clinical effects need to be confirmed by large multicenter randomized controlled trials. |
