| ABSTRACT Objective:To investigate the distribution and drug resistance of pathogens in elder patients causing ventilator associated pneumonia (VAP) to choose more reasonable treatment programs. Methods:586 cases elder of patients receiving mechanical ventilation were selected in our hospital from January 2009 to January 2014. And drug resistance of pathogens from VAP patients' lower respiratory tract sputum specimens were analyzed.Results: Among 586 elder patients treated with mechanical ventilation, 198 patients causing ventilator associated pneumonia (incidence rate 33.8%), and 224 strains of pathogens were isolated. Among them, the isolation proportion of the gram negative bacilli was the highest (72.8%), followed by the gram positive bacteria (17.4%) and the fungi (9.8%). The Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli were the top three species of of the gram negative bacteria, sharing of 23.2%,16.1%,8.9%, respectively. The isolation proportion of the pan resistant for Acinetobacter baumanniiand Pseudomonas aeruginosa was 97.69% and 22.2%, respectively; the isolation proportion of the ESBLs producing bacteria was 55.0%. Among the gram positive bacteria, the Staphylococcus aureus and Staphylococcus epidermidis were the most common bacteria and the isolation proportion of methicillin resistant Staphylococcus aureus (MRAS) and methicillin resistant Staphylococcus epidermidis(MRSE) were 68.2% and 66.7%, respectively. Conclusion:The gram negative bacteria are predominant pathogens causing VAP, and are highly drug resistant. Monitoring of drug resistance of the pathogens timely is crucial to guide drug use rationaly. |
