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| 我院妇产科抗菌药物不良反应/事件相关因素分析 |
| Relative Factors of the Adverse Drug Reactions/Events of Antibacterial Drugs in Department of Gynaecology and Obstetrics |
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| DOI： |
| 中文关键词: 抗菌药物 药物不良反应/事件 年龄 超剂量 |
| 英文关键词:Antibacterial drug Adverse drug reactions/events Age Overdose |
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| 中文摘要: |
| 摘 要 目的:了解抗菌药品不良反应/事件（ADR/ADE）发生特点及相关因素，为安全用药提供依据。方法：回顾性分析2011～2013年我院妇产科上报的抗菌药物ADR/ADE报告。结果：165例ADR/ADE患者，平均年龄（28.76±6.80）岁，年龄越高，ADR/ADE发生率越高；青霉素类药物ADR/ADE发生率2.41%，居首位；头孢菌素类药物ADR/ADE例数占73.33%，但ADR/ADE发生率低于均值0.47%；超剂量使用与ADE发生有显著关系，超剂量使用头孢呋辛、头孢曲松发生ADE，P值分别为0.002,0.034；165例ADR/ADE患者，静脉滴注149例，肌内注射12例，口服4例。结论：加强抗菌药物处方审核和护理干预，加强ADR高发生率药物监测，严格控制输液量，以减少或避免ADR/ADE发生。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the features and relative factors of the adverse drug reactions/events of antibacterial drugs for rational clinical use. Methods:A total of 165ADR/ADE cases from obstetrics were retrospective analysis from 2011 to 2013.Results:Their average age were (28.76±6.80) years old.The older had more higher incidence rate of ADR/ADE.Pencillin type drugs had the highest incidence rate,which was 2.41%.The ADR/ADE cased by cephalosporins whose occurrence rate was lower than the mean accounted for 73.33%.Overdose use significantly increased the incidence rate of ADE,especially cefuroxime sodium for injection and ceftriaxone sodium for injection(P=0.002,P=0.034).149 ADR/ADE cases(90.30%)were induced by method of intravenous drip,followed by intramuscular injection(7.27%),and oral administration accounted for 2.43%.Conclusion:It's important to strengthen prescription checking and nursing intervention,and govern medicine injection,so as to reduce the occurrence of ADR/ADE. |
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