| ABSTRACT Objective:To discuss curative effect and security comparison of dezocine and fentanyl to prevent stretch reaction in appendectomy.Methods: 90 cases of patients with appendectomy under epidural block were divided into dezocine group and fentanyl group at random. The patients in two groups were given routine epidural anesthesia, and the patients in dezocine group were given dezocine 0.1 mg·kg-1 by intravenous injection before skinincision, which last until the end of operation with the dose of 1.5-2μg·kg-1·min-1 by minipump, while the patients in fentanyl group were given fentanyl 1 μg·kg-1 by intravenous injection before skinincision, , which last until the end of operation with the dose of 0.2-0.3 μg·kg-1·min-1 by minipump. The changes of vital signs (SBP, DBP, HR, SpO2) of patients in two groups before the operation (T0), at skinincision time (T1), pulling the appendix (T2) and the end of operation (T3) were observed and compared. Meanwhile, the stretch reaction and postoperative untoward effect of patients in two groups during the operation were observed. Results:Compared with T0, the HR, SBP, DBP and SpO2 of patients in dezocine group at T1, T2 and T3 showed no obvious change (P>0.05), while the HR, SBP and DBP of patients in fentanyl group at T1, T2 and T3 obviously rose (P<0.05 or P<0.01), and SpO2 obviously declined (P<0.05 or P<0.01). Compared with dezocine, HR, SBP and DBP of patients in fentanyl group at T1, T2 and T3 obviously rose (P<0.05 or P<0.01), while SpO2 declined (P<0.05 or P<0.01). The intraoperative stretch reaction and untoward effect occurrence rates of patients in dezocine group were much lower than those in fentanyl group (P<0.05).Conclusion:Compared with fentanyl, the application of dezocine in the appendectomy under epidural block as adjunctive therapy can achieve more favorable curative effect, with more stable vital signs of patients and less occurrence rates of stretch reaction and postoperative untoward effect, which is a safe and effective anesthesia method. |
