| ABSTRACT Objective: To compare the curative effect and adverse drug reaction of concurrent chemotherapy and sequential chemoradiotherapy for locally advanced non smallcell lung cancer(NSCLC). Methods:268 patients with locally advanced NSCLC were divided randomly into synchronous groupand sequential group. Synchronous group treated with docetaxel +DDP chemotherapy and combined with concurrent radiotherapy for first day beginning, 2 cycle synchronization. Sequential group treated with docetaxel +DDP chemotherapy, after two cycles three dimensional conformal or intensity modulated radiation therapy was used. After the end of radiotherapy were chemotherapy 2 cycle again in two groups.The short termefficacy, life quality and adverse drug reaction of two groups were compared. Results:The total alleviation rates of two groups was 73.13% and 50.75%, differences were statistically significant (P<0.05).The increasing rate of life quality of synchronous group was 22.39%, which was significantly higher than the 11.94% of sequential group (P<0.05). Adverse drug reactions, including the level 3-4 radioactive pneumonia, the level 3 4 radioactive esophagitis, level 3-4 the digestive tract reaction, and the level 3 4 bone marrowsuppression of two groups, there were no statistically significant difference (P>0.05). Conclusion:The concurrent chemotherapy can significantly enhance the curative effect to the locally advanced NSCLC, improve life quality, but it was not obvious to increased adverse drug reactions. |
