| ABSTRACT Objective:To research on patients with sepsis in CVVHDF mode pharmacokinetic characteristics of vancomycin, and provide basis for the rational use of drugs to patients with sepsis.Methods: Twenty patients with sepsis were randomly divided into two groups, the renal replacement therapy in CVVHDF mode of 10 patients were included in the team, the remaining 10 cases as control group. All patients with a single given vancomycin 1.0g, multi point draw blood specimens to test, the blood drug concentration, got the vancomycin in pharmacokinetic parameters of the patient’s body.Results:Vancomycin in sepsis patients pharmacokinetic parameters in line with the second chamber model.Compared with the control group, the team drug distribution in the body more rapidly, the difference of the t1/2α、t1/2β、CL、AUC0-∞ between the two groups was statistically significant (P<0.05).24h after administration, the creatinine clearance rate of the team was increased significantly than before(P<0.05), and was significantly higher than that of the control group(P<0.05). Conclusion:Vancomycin in sepsis patients show the pharmacokinetic parameters of secondary chamber model use CVVHDF mode to treat sepsis patients, the pharmacokinetic parameters of vancomycin has obvious changes, compared to the patients with renal replacement therapy, the distribution of vancomycin in the body speed and rate is accelerated. Conventional dose of vancomycin in CVVHDF mode is safe. |
