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| 头孢菌素致慢性肾衰竭患者抗生素脑病25例回顾性分析 |
| Retrospective Analysis of Antibiotics Encephalopathy Caused by Cephalosporin Antibiotics in Patients with Chronic Renal Failure |
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| DOI： |
| 中文关键词: 头孢菌素 慢性肾衰竭 抗生素脑病 |
| 英文关键词:Cephalosporin antibiotic Chronic renal failure Antibiotics encephalopathy |
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| 中文摘要: |
| 摘 要 目的:探讨慢性肾衰竭患者应用头孢菌素后出现抗生素脑病的机制、临床表现及应对策略。方法：回顾2010年3月～2013年3月２５例使用头孢菌素后出现抗生素脑病的慢性肾衰竭患者的临床资料，分析其发生抗生素脑病的相关因素及临床特点。结果：引起抗生素脑病的头孢菌素种类较多，最常见的为头孢他啶。起病多在使用头孢菌素3～6 d后，症状多样而无特异性，老年患者症状尤重。结论：慢性肾衰竭患者使用头孢菌素易出现抗生素脑病，使用中需严格按照肾小球滤过率调整剂量。一旦出现抗生素脑病需立刻停药，给予对症处理或加强血液透析。经正确处理大部分患者可恢复。 |
| 英文摘要: |
| ABSTRACT Objective:Discussing the mechanism,outcome and treatment of antibiotics encephalopathy associated with the use of cephalosporin antibiotics in chronic renal failure. Methods:Retrospection based on 25 chronic renal failure who have developed antibiotics encephalopathy associated with the use of cephalosporin antibiotics in the past three years. Analyse the influential factors and the clinical characteristic of antibiotics encephalopathy.Results:There are many kinds of cephalosporin antibiotic which cause antibiotics encephalopathy. Ceftazidime is the commonest. The onset is typically 3 to 6 days after the use of cephalosporin antibiotic. The symptoms are varied without specificity which are serious with elder patients. Conclusion:Patients with chronic renal failure are likely to develop antibiotics encephalopathy after the use of cephalosporin antibiotics. eGFR should be used to adjust antibiotics drug dosage. The cephalosporin antibiotic should be stopped at the first sign of any symptoms of antibiotics encephalopathy for patients with chronic renal failure. Most of patients will recover after applying symptomatic treatment strengthen hemodialysis. |
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