| ABSTRACT Objective:To investigate the prevalence of multiple drug resistant organism (MDRO) infection characteristics and related factors for the development of clinical treatment and a reasonable basis for hospital infection control measures．Methods: To statistic the MDRO separated from the clinical specimens in 2013 and analyze clinical distribution characteristic and drug resistance． Results:The constituent ratio of MDRO was 58.05%.The constituent ratio was higher in the the male patients, elderly patients, patients with respiratory disease, cerebral vascular, accident, traumatic brain injury, cancer and multiple trauma, patients staying in hospital for 10 20d , patient with treatment in autumn or winter. MDRO mainly distributed in ICU（17.67%）,the neurosurgery department（15.82%）and respiratory department（10.68%）.The main specimen sources of MDRO was sputum, secretion and urine. The different was that MDRO had different constituent ratio. Carbapenem resistant Escherichia coli, Carbapenem resistant Pseudomonas aeruginosa, Carbapenem resistant Acinetobacter baumanii, Carbapenem resistant Pseudomonas aeruginosa,Vancomycin resistant Enterococcus Faliscan and Enterococcus faecium were detected. The constituent ratio of methicillin resistant Staphylococcus aureus (MRSA) was 74%, the constituent ratio of methicillin resistant Staphylococcus epidermidis (MRSE) was 72%. The different MDRO had different drug desistance,Cefoperazone sulbactam were the most active antibiotic to G-, Vancomycin and Linezolid were the most active antibiotic to G+. Before the culturing the MDRO, the all patients had history of using the antimicrobial agents, β-Lactams antimicrobial agents was one of the most commonly used drugs. Conclusion:The drug resistance of multi drug resistant MDRO is very serious. It is very important to select proper antibiotics according to the result of susceptibility tests. Hospital should strengthen the monitoring of MDRO to prevent and control the outbreak and prevalence of nosocomial infections. |
