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| 宫颈环形电切除术后保妇康栓治疗人乳头瘤病毒阳性宫颈糜烂 |
| Efficacy of Baofukang Suppository after LEEP in Patients with HPV positive Cervical Erosion |
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| DOI： |
| 中文关键词: 宫颈糜烂 人乳头瘤病毒 宫颈环形电切除术 保妇康栓 复方沙棘籽油栓 |
| 英文关键词:Cervical erosion Human papilloma virus LEEP Baofukang suppository |
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| 中文摘要: |
| 摘 要 目的:观察宫颈环形电切除术（LEEP）后采用保妇康栓治疗人乳头瘤病毒（HPV）阳性宫颈糜烂的疗效。方法：168例HPV阳性宫颈糜烂患者分为观察组和对照组。两组患者均行LEEP术治疗，术后常规予重组人干扰素α2a注射液300万IU，im qd。对照组术后1个月后予复方沙棘籽油栓2.7 g qd阴道给药，观察组术后1个月后予保妇康栓3.48 g qd阴道给药。疗程均为2周。观察两组患者各项症状改善情况，HPV DNA负荷量及转阴率，比较两组疗效。结果：治疗后，两组患者白带异常、腰骶疼痛、下腹胀痛及接触性出血等临床症状均得到明显改善（P<0.01），且观察组症状改善状况明显优于对照组（P<0.01）。两组患者的HPV DNA负荷量均明显降低（P<0.01），且观察组治疗后负荷量明显低于对照组（P<0.01），HPV转阴率明显高于对照组（P<0.01）。观察组总有效率（95.45%）明显高于对照组（P<0.01）。结论：LEEP后采用保妇康栓治疗HPV阳性宫颈糜烂疗效显著，能明显改善患者各项症状，降低HPV DNA负荷量，提高HPV转阴率。 |
| 英文摘要: |
| ABSTRACT Objective:To study the efficacy of Baofukang suppository after LEEP(Loop Electrosurgical Excision Procedure) in the patients with Human papillomavirus (HPV) positive cervical erosion. Methods:168 cases of patients with HPV positive cervical erosion were randomly divided into observation group and control group.Two groups were treated with LEEP surgery and were given IFN α2a 3 million IU,im qd.One month after the surgery, the control group were treated with Seabuckthorn seed oil suppository, and the observation group were treated with Baofukang suppository. After 2 weeks treatment , the improvement of symptoms, HPV DNA load and negative rate of the two groups were recorded, and response evaluation criteria were used to assesse the efficacy of two groups. Results:After treatment , abnormal vaginal discharge , lumbosacral pain, abdominal pain and contact bleeding symptoms of the two groups were significantly improved (P<0.01).In addition, the improvement of symptoms in observation group was greater than control group(P<0.01). HPV DNA load of the two groups were significantly lower(P<0.01).The observation group had lower load than control group(P<0.01). HPV negative rate in observation group was significantly higher than the rate of control grouo .The two groups was statistically significant(P<0.01).The total treatment efficiency(95.45%) of the observation group was significantly higher than the control group(P<0.01). Conclusion:The efficacy of Baofukang suppository in the patients with HPV positive cervical erosion is significant，and worthy of clinical application . |
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