| ABSTRACT Objective:To observe the clinical effects of terlipressin on cirrhosis with refractory ascites. Methods: 61 cases of cirrhosis patients with refractory ascites were randomly divided into control group(29 cases) and observation group(32 cases). The patients in the control group were received conventional therapy, while the patients in observation group were treated with terlipressin 1 mg 2 times/d by micro pump on the basis of conventional therapy. Two groups were all treated for 15 days. Before and after the treatment, the clinical indexes such as weight, abdomen circumference, serum creatinine and other biochemical indicators were observed. Two kinds of treatments were inferred whether there were effect and efficacy differences by using multivariate analysis and single factor analyse. Results: Multivariate analysis showed that clinical and biochemical indicators of the two groups were improved obviously after treatment (P<0.001 or 0.01). There were significant differences between the two groups in the clinical indicators （P=0.002）and biochemical indicators（P<0.001） compared before and after treatment. By Single factor analysis, there were improvement in weight, abdomen circumference, ascites depth, urine volume, creatinine and urinary sodium in observation group, but there were improvement only in ascites depth, urine volume, urinary sodium in control group. Ascites depth reduction, urine volume increased, creatinine decreased and increased urinary sodium excretion in the observation group were better than those in the control group. Conclusion:The clinical indicators and biochemical indicators were improved in cirrhosis patients with refractory ascites by the combination of conventional treatment and terlipressin.The clinical effects of combination therapy was superior to the conventional treatment. |
