| ABSTRACT Objective: To discuss the clinical effect of atorvastatin combined with fenofibrate on the treatment of ischemic stroke and its influence on blood lipid, high-sensitivity C-reactive protein（hs-CRP）level . Methods:64 cases of ischemic stroke were divided into observation group and control group at random，two groups of patients were given routine symptomatic treatment, control group (32 patients) was given atorvastatin tablet 20 mg，po qn, treatment for 3 months; the treatment group (32 cases) was given fenofibrate capsule 0.2 g，po qd based on the control group, treatment for 3 months. The nervefunction deficit score， blood lipid，hs-CRP level before and after treatment the two groups，and the adverse reactions of the two groups were compared .In one year follow up,the recurrence rate of two groups were observed.Results:after treatment, the CNDF score of two groups were significantly decreased, the score of treatment group was significantly lower than the control group (P<0.05). After treatment ,the blood lipid and serum hs-CRP levels of observation group were all improved significantly than before (P<0.05), and were much better than that of the control group (P<0.05),but there were no significantly difference on the serum hs-CRP level and blood lipid of control group(P>0.05).The incidence rate of adverse reaction of the two groups had no statistically significant (P>0.05). After one year of follow up, the recurrence rate of control group was much higher than that of the observation group(P<0.05). Conclusion:The effect of atorvastatin combined with fenofibrate for ischemic stroke is significantly, can effectively regulate blood lipid, reduce the serum hs-CRP levels and adverse cerebrovascular event recurrence, is worth promoting in clinical use. |
