| ABSTRACT Objective:To observe the clinical efficacy of levocarnitine on chronic renal failure complicated with coronary heart disease / arrhythmia，and its influence on oxidized low density lipoprotein (ox-LDL) concentration of the patients. Methods:64 cases of patients with chronic renal failure complicated with coronary heart disease/arrhythmia were randomly divided into control group and observation group , each group had 32 cases . The control group received hemodialysis and routine treatment, the observation group were treated by levocarnitine based on the control group, the two groups were treated for 3 months, the clinical effect, left ventricular diastolicdiameter (LVDD). left ventricular end systolic diameter (LVSD), left ventricular ejection fraction(LVEF), left ventricular fractional shortening (LVSF), serum ox-LDL concentration before and after the treatment was compared between two groups . Results:After 3 months of treatment, the cardiac function of two groups patients was significantly improved(P<0.05), and the observation group improved more significantly than before(P＜0.05)and the control group(P<0.05).After treatment, the level of ox-LDL of the observation group was significantly lower than the control group(P<0.05).The total clinical effective rate of the observation group were significantly higher than that of the control group(P<0.05).Conclusion:Levocarnitine combined with routine treatment can significantly improve cardiac function, reduced the frequency of chronic renal failure complicated with cardiac arrhythmia in patients with coronary heart disease and angina attack, but also can effectively reduce the level of serum ox-LDL. |
